Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand

The potent costimulatory effect of CD137 has been implicated in several murine autoimmune disease models. CD137 costimulates and polarizes antigen-specific T cells toward a potent Th1/Tc1 response, and is essential for the development of experimental autoimmune encephalomyelitis (EAE), a murine mode...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Wong, Hiu Yi, Prasad, Ankshita, Gan, Shu Uin, Chua, John Jia En, Schwarz, Herbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677239/
https://ncbi.nlm.nih.gov/pubmed/33240262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.571964
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