Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus

The CD137—CD137 ligand (CD137L) costimulatory system is a critical immune checkpoint with pathophysiological implications in autoimmunity. In this study, we investigated the role of CD137L-mediated costimulation on renal, cutaneous and cerebral manifestations in lupus and the underlying immunologica...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Mak, Anselm, Dharmadhikari, Bhushan, Kow, Nien Yee, Thamboo, Thomas Paulraj, Tang, Qianqiao, Wong, Lik Wei, Sajikumar, Sreedharan, Wong, Hiu Yi, Schwarz, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607944/
https://ncbi.nlm.nih.gov/pubmed/31297111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01411
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