Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[(18)F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [(18)F]-VXS

Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE). Although they share a common mechanism of AChE reactivation, the rate and amount of oxime that enters the brain are critical to the efficacy, a process linked to the oxime structure and charge. Using a platform based o...

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Foilsithe in:Ann N Y Acad Sci
Main Authors: Hayes, Thomas R., Blecha, Joseph E., Chao, Chih-Kai, Huynh, Tony L., VanBrocklin, Henry F., Zinn, Kurt R., Taylor, Palmer W., Gerdes, John M., Thompson, Charles M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677195/
https://ncbi.nlm.nih.gov/pubmed/32436233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.14363
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