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An improved radiosynthesis of O-(2-[(18)F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer

O-(2-Fluoroethyl)-O-(p-nitrophenyl) methylphosphonate 1 is an organophosphate cholinesterase inhibitor that creates a phosphonyl-serine covalent adduct at the enzyme active site blocking cholinesterase activity in vivo. The corresponding radiolabeled O-(2-[(18)F]fluoroethyl)-O-(p-nitrophenyl) methyl...

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Detalles Bibliográficos
Publicado en:J Labelled Comp Radiopharm
Main Authors: Neumann, Kiel D., Thompson, Charles M., Blecha, Joseph E., Gerdes, John M., VanBrocklin, Henry F.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031433/
https://ncbi.nlm.nih.gov/pubmed/28406525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3511
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