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An improved radiosynthesis of O-(2-[(18)F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer
O-(2-Fluoroethyl)-O-(p-nitrophenyl) methylphosphonate 1 is an organophosphate cholinesterase inhibitor that creates a phosphonyl-serine covalent adduct at the enzyme active site blocking cholinesterase activity in vivo. The corresponding radiolabeled O-(2-[(18)F]fluoroethyl)-O-(p-nitrophenyl) methyl...
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| Publicado no: | J Labelled Comp Radiopharm |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6031433/ https://ncbi.nlm.nih.gov/pubmed/28406525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3511 |
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