Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), had higher affinity at opio...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Obeng, Samuel, Kamble, Shyam H., Reeves, Morgan E., Restrepo, Luis F., Patel, Avi, Behnke, Mira, Chear, Nelson J.-Y., Ramanathan, Surash, Sharma, Abhisheak, León, Francisco, Hiranita, Takato, Avery, Bonnie A., McMahon, Lance R., McCurdy, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7676998/
https://ncbi.nlm.nih.gov/pubmed/31834797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01465
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