Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), had higher affinity at opio...

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Opis bibliograficzny
Wydane w:J Med Chem
Główni autorzy: Obeng, Samuel, Kamble, Shyam H., Reeves, Morgan E., Restrepo, Luis F., Patel, Avi, Behnke, Mira, Chear, Nelson J.-Y., Ramanathan, Surash, Sharma, Abhisheak, León, Francisco, Hiranita, Takato, Avery, Bonnie A., McMahon, Lance R., McCurdy, Christopher R.
Format: Artigo
Język:Inglês
Wydane: 2019
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7676998/
https://ncbi.nlm.nih.gov/pubmed/31834797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01465
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