Role of Nucleotide Excision Repair and p53 in Zidovudine (AZT)-Induced Centrosomal Deregulation

The nucleoside reverse transcriptase inhibitor zidovudine (AZT) induces genotoxic damage that includes centrosomal amplification (CA>2 centrosomes/cell) and micronucleus (MN) formation. Here we explored these end points in mice deficient in DNA repair and tumor suppressor function to evaluate the...

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Publicat a:Environ Mol Mutagen
Autors principals: Momot, Dariya, Nostrand, Terri A., John, Kaarthik, Ward, Yvona, Steinberg, Seth M., Liewehr, David J., Poirier, Miriam C., Olivero, Ofelia A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7675294/
https://ncbi.nlm.nih.gov/pubmed/25073973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21889
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