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Role of Nucleotide Excision Repair and p53 in Zidovudine (AZT)-Induced Centrosomal Deregulation
The nucleoside reverse transcriptase inhibitor zidovudine (AZT) induces genotoxic damage that includes centrosomal amplification (CA>2 centrosomes/cell) and micronucleus (MN) formation. Here we explored these end points in mice deficient in DNA repair and tumor suppressor function to evaluate the...
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| Gepubliceerd in: | Environ Mol Mutagen |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7675294/ https://ncbi.nlm.nih.gov/pubmed/25073973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21889 |
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