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Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations
BACKGROUND: Na(v)1.5 cardiac Na(+) channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na(+) channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric inter...
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| izdano v: | Front Physiol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7674773/ https://ncbi.nlm.nih.gov/pubmed/33250780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.589386 |
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