Rationale and design of the Medical Research Council's Precision Medicine with Zibotentan in Microvascular Angina (PRIZE) trial

Microvascular angina is caused by cardiac small vessel disease, and dysregulation of the endothelin system is implicated. The minor G allele of the non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression of the endothelin 1 gene in human vascular cells, increasing circulating c...

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Pubblicato in:Am Heart J
Autori principali: Morrow, Andrew J, Ford, Thomas J, Mangion, Kenneth, Kotecha, Tushar, Rakhit, Roby, Galasko, Gavin, Hoole, Stephen, Davenport, Anthony, Kharbanda, Rajesh, Ferreira, Vanessa M, Shanmuganathan, Mayooran, Chiribiri, Amedeo, Perera, Divaka, Rahman, Haseeb, Arnold, Jayanth R., Greenwood, John P., Fisher, Michael, Husmeier, Dirk, Hill, Nicholas A, Luo, Xiaoyu, Williams, Nicola, Miller, Laura, Dempster, Jill, Macfarlane, Peter W, Welsh, Paul, Sattar, Naveed, Whittaker, Andrew, Connachie, Alex Mc, Padmanabhan, Sandosh, Berry, Colin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mosby 2020
Soggetti:
Trial Design
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674581/
https://ncbi.nlm.nih.gov/pubmed/32942043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ahj.2020.07.007
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