The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B

AMFR/gp78 and USP13 are a pair of ubiquitin ligase and deubiquitinase that ensure the accuracy of endoplasmic reticulum-associated degradation (ERAD). Depletion of USP13 leads to caspase activation and cleavage of the ERAD chaperone BAG6, which is reversed by knockdown of AMFR. However, the mechanis...

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Udgivet i:iScience
Main Authors: Chu, Yuanyuan, Dong, Xingqi, Kang, Yingjin, Liu, Jingnan, Zhang, Tao, Yang, Cuiwei, Wang, Zhangshun, Shen, Wangchen, Huo, Huanhuan, Zhuang, Min, Lu, Junxia, Liu, Yanfen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674511/
https://ncbi.nlm.nih.gov/pubmed/33241194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101708
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