AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies

Mutations in the human desmin gene cause autosomal-dominant and recessive cardiomyopathies and myopathies with marked phenotypic variability. Here, we investigated the effects of adeno-associated virus (AAV)-mediated cardiac wild-type desmin expression in homozygous desmin knockout (DKO) and homozyg...

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Publicat a:Gene Ther
Autors principals: Ruppert, T., Heckmann, M. B., Rapti, K., Schultheis, D., Jungmann, A., Katus, H. A., Winter, L., Frey, N., Clemen, C. S., Schröder, R., Müller, O. J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674151/
https://ncbi.nlm.nih.gov/pubmed/32322014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-020-0147-7
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