Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity

Ribavirin has been used for 25 years to treat patients with chronic hepatitis C virus (HCV) infection; however, its antiviral mechanism of action remains unclear. Here, we studied virus evolution in a subset of samples from a randomized 24-week trial of ribavirin monotherapy versus placebo in chroni...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Mejer, Niels, Fahnøe, Ulrik, Galli, Andrea, Ramirez, Santseharay, Weiland, Ola, Benfield, Thomas, Bukh, Jens
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2020
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674049/
https://ncbi.nlm.nih.gov/pubmed/32928732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01417-20
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