Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome

Immune checkpoint inhibitors (ICIs) show promise, but most patients do not respond. We identify and validate biomarkers from extracellular vesicles (EVs), allowing non-invasive monitoring of tumor- intrinsic and host immune status, as well as a prediction of ICI response. We undertook transcriptomic...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Shi, Alvin, Kasumova, Gyulnara G., Michaud, William A., Cintolo-Gonzalez, Jessica, Díaz-Martínez, Marta, Ohmura, Jacqueline, Mehta, Arnav, Chien, Isabel, Frederick, Dennie T., Cohen, Sonia, Plana, Deborah, Johnson, Douglas, Flaherty, Keith T., Sullivan, Ryan J., Kellis, Manolis, Boland, Genevieve M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673759/
https://ncbi.nlm.nih.gov/pubmed/33188016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb3461
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