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Genome editing strategies for fetal hemoglobin induction in beta-hemoglobinopathies

Genome editing to correct a defective β-globin gene or induce fetal globin (HbF) for patients with beta-hemoglobinopathies has the potential to be a curative strategy available to all. HbF reactivation has long been an area of intense interest given the HbF inhibition of sickle hemoglobin (HbS) poly...

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Publicat a:Hum Mol Genet
Autors principals: Demirci, Selami, Leonard, Alexis, Tisdale, John F
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673473/
https://ncbi.nlm.nih.gov/pubmed/32406490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa088
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