Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure

BACKGROUND: Acetaminophen (APAP) overdose is one of the major etiologies of liver failure. Hepatocyte necrosis induced by toxic metabolites of APAP can activate proinflammatory responses, including elastase-expressing neutrophils, to exacerbate liver injury. Myeloid-derived suppressor cells (MDSCs)...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hsu, Chen-Yu, Lin, Yung-Chang, Chang, Li-Yuan, Huang, Sheng-Kai, Huang, Chien-Hao, Yang, Chan-Keng, Huang, Ching-Tai, Lin, Chun-Yen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673381/
https://ncbi.nlm.nih.gov/pubmed/33250891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.574839
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