Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma

BACKGROUND: The utility of O(6)-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with glioblastoma (GBM) has been established. However, the number of CpG sites that must be methylated to cause transcriptional silencing remains unclear, an...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Hanihara, Mitsuto, Miyake, Kunio, Watanabe, Atsushi, Yamada, Yuriko, Oishi, Naoki, Kawataki, Tomoyuki, Inukai, Takeshi, Kondo, Tetsuo, Kinouchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672949/
https://ncbi.nlm.nih.gov/pubmed/33203454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00968-5
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