The Prognostic Value of Pyrosequencing-Detected MGMT Promoter Hypermethylation in Newly Diagnosed Patients with Glioblastoma

O6-methylguanine-DNA-methyltransferase (MGMT) has emerged as a relevant predictor of therapeutic response and good prognosis in patients with glioblastoma (GBM). Transcriptionally active MGMT rapidly removes the alkyl adducts, preventing the formation of cross-links and thereby causing resistance to...

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Detalhes bibliográficos
Publicado no:Dis Markers
Main Authors: Villani, Veronica, Casini, Beatrice, Pace, Andrea, Prosperini, Luca, Carapella, Carmine M., Vidiri, Antonello, Fabi, Alessandra, Carosi, Mariantonia
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548097/
https://ncbi.nlm.nih.gov/pubmed/26347581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/604719
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