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Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats

Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in pulmonary arterial hypertension. We investigated effects of tadalafil and macitentan alone or...

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Publicado en:Pulm Circ
Autores principales: Mamazhakypov, Argen, Weiß, Astrid, Zukunft, Sven, Sydykov, Akylbek, Kojonazarov, Baktybek, Wilhelm, Jochen, Vroom, Christina, Petrovic, Aleksandar, Kosanovic, Djuro, Weissmann, Norbert, Seeger, Werner, Fleming, Ingrid, Iglarz, Marc, Grimminger, Friedrich, Ghofrani, Hossein A., Pullamsetti, Soni S., Schermuly, Ralph T.
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE Publications 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672745/
https://ncbi.nlm.nih.gov/pubmed/33240483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045894020947283
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