Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases

Removal of ribonucleotides (rNMPs) incorporated into the genome by the ribonucleotide excision repair (RER) is essential to avoid genetic instability. In eukaryotes, the RNaseH2 is the only known enzyme able to incise 5′ of the rNMP, starting the RER process, which is subsequently carried out by rep...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Riva, Valentina, Garbelli, Anna, Casiraghi, Federica, Arena, Francesca, Trivisani, Claudia Immacolata, Gagliardi, Assunta, Bini, Luca, Schroeder, Martina, Maffia, Antonio, Sabbioneda, Simone, Maga, Giovanni
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672437/
https://ncbi.nlm.nih.gov/pubmed/33137198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa948
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