Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

BACKGROUND: Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum, and st...

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Bibliografiske detaljer
Udgivet i:Mol Autism
Main Authors: Jacot-Descombes, Sarah, Keshav, Neha U., Dickstein, Dara L., Wicinski, Bridget, Janssen, William G. M., Hiester, Liam L., Sarfo, Edward K., Warda, Tahia, Fam, Matthew M., Harony-Nicolas, Hala, Buxbaum, Joseph D., Hof, Patrick R., Varghese, Merina
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671669/
https://ncbi.nlm.nih.gov/pubmed/33203459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00393-8
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