Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

BACKGROUND: Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum, and st...

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Dades bibliogràfiques
Publicat a:Mol Autism
Autors principals: Jacot-Descombes, Sarah, Keshav, Neha U., Dickstein, Dara L., Wicinski, Bridget, Janssen, William G. M., Hiester, Liam L., Sarfo, Edward K., Warda, Tahia, Fam, Matthew M., Harony-Nicolas, Hala, Buxbaum, Joseph D., Hof, Patrick R., Varghese, Merina
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671669/
https://ncbi.nlm.nih.gov/pubmed/33203459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00393-8
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