Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies

PURPOSE: Drug delivery into the inner ear across the intact tympanic membrane (TM) has been a challenge in the treatment of inner ear disorders. In this study, nano-sized carriers were formulated for improving the non- invasive oto-topical delivery of caroverine for the treatment of tinnitus. METHOD...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Farrah, Amira Yousry, Al-mahallawi, Abdulaziz M, Basalious, Emad B, Nesseem, Demiana I
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671472/
https://ncbi.nlm.nih.gov/pubmed/33223827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S259172
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