CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis

BACKGROUND: CXCL13 is a B and T lymphocyte chemokine that mediates neuroinflammation through its receptor CXCR5. This chemokine is highly expressed by motoneurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) SOD1G93A (mSOD1) mice during the disease, particularly in fast-progressing mice. Accordingly...

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Библиографические подробности
Опубликовано в: :EBioMedicine
Главные авторы: Trolese, Maria Chiara, Mariani, Alessandro, Terao, Mineko, de Paola, Massimiliano, Fabbrizio, Paola, Sironi, Francesca, Kurosaki, Mami, Bonanno, Silvia, Marcuzzo, Silvia, Bernasconi, Pia, Trojsi, Francesca, Aronica, Eleonora, Bendotti, Caterina, Nardo, Giovanni
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670099/
https://ncbi.nlm.nih.gov/pubmed/33161233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103097
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