TNFAIP3 Plays a Role in Aging of the Hematopoietic System

Hematopoietic stem and progenitor cells (HSPC) experience a functional decline in response to chronic inflammation or aging. Haploinsufficiency of A20, or TNFAIP3, an innate immune regulator, is associated with a variety of autoimmune, inflammatory, and hematologic malignancies. Based on a prior ana...

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Pubblicato in:Front Immunol
Autori principali: Smith, Molly A., Culver-Cochran, Ashley E., Adelman, Emmalee R., Rhyasen, Garrett W., Ma, Averil, Figueroa, Maria E., Starczynowski, Daniel T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670064/
https://ncbi.nlm.nih.gov/pubmed/33224133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.536442
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