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Deletion of c-Jun N-terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice
OBJECTIVE. Determine the role of c-Jun N-terminal kinase (JNK) signaling in the development of osteoarthritis (OA) induced by joint injury and aging in mice. METHODS. Destabilization of the medial meniscus (DMM) or sham surgery was performed on 12 week-old mice and OA evaluated 8 weeks after surgery...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669715/ https://ncbi.nlm.nih.gov/pubmed/32418287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41312 |
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