Deletion of c-Jun N-terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice

OBJECTIVE. Determine the role of c-Jun N-terminal kinase (JNK) signaling in the development of osteoarthritis (OA) induced by joint injury and aging in mice. METHODS. Destabilization of the medial meniscus (DMM) or sham surgery was performed on 12 week-old mice and OA evaluated 8 weeks after surgery...

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I publikationen:Arthritis Rheumatol
Huvudupphovsmän: Loeser, Richard F., Kelley, Kathryn L., Armstrong, Alexandra, Collins, John A., Diekman, Brian O., Carlson, Cathy S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669715/
https://ncbi.nlm.nih.gov/pubmed/32418287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41312
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