Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2

Mitogen-activated protein kinases, including c-Jun NH2-terminal kinase (JNK), play an important role in the development and function of a large variety of tissues. The skeletal phenotype of JNK1 and JNK2 double-knockout (dKO) mice (JNK1(fl/fl)Col2-Cre/JNK2(−/−)) and control genotypes were analyzed a...

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Bibliografske podrobnosti
izdano v:Am J Pathol
Main Authors: Ulici, Veronica, Kelley, Kathryn L., Longobardi, Lara, McNulty, Margaret A., Livingston, Eric W., Bateman, Ted A., Séguin, Cheryle A., Louer, Craig R., Loeser, Richard F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446226/
https://ncbi.nlm.nih.gov/pubmed/30664861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.12.010
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