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Targeting CD73 to augment cancer immunotherapy
CD73 (ecto-5′-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit excessive immune response. However, tumors take adva...
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| Udgivet i: | Curr Opin Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669683/ https://ncbi.nlm.nih.gov/pubmed/32777746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2020.07.001 |
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