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CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers

CD73, a cell surface 5′nucleotidase that generates adenosine, has emerged as an attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment to dampen antitumor immune cell evasion. Decades of studies have paved the way for these findings, starting with the discovery o...

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Опубликовано в: :Front Immunol
Главные авторы: Harvey, Jerry B., Phan, Luan H., Villarreal, Oscar E., Bowser, Jessica L.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174602/
https://ncbi.nlm.nih.gov/pubmed/32351498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00508
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