Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma

PURPOSE: The extracellular matrix (ECM) is an intriguing yet understudied component of therapy resistance. Here we investigated the role of ECM remodeling by the collagenase MT1-MMP in conferring resistance of BRAF-mutant melanoma to BRAF inhibitor therapy. EXPERIMENTAL DESIGN: Publicly available RN...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Marusak, Charles, Thakur, Varsha, Li, Yuan, Freitas, Juliano T., Zmina, Patrick M., Thakur, Vijay S., Chang, Mayland, Gao, Ming, Tan, Jiufeng, Xiao, Min, Lu, Yiling, Mills, Gordon, Flaherty, Keith T., Frederick, Dennie T., Miao, Benchun, Sullivan, Ryan J., Moll, Tabea, Boland, Genevieve, Herlyn, Meenhard, Zhang, Gao, Bedogni, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669662/
https://ncbi.nlm.nih.gov/pubmed/32820016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2773
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