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Treatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1
The nucleoside analog 5-aza-2’-deoxycytidine (5-aza-dC) is used to treat some hematopoietic malignancies. The mechanism of cell killing depends upon DNMT1, but is otherwise not clearly defined. Here we show that PARP1 forms covalent DNA adducts in human lymphoblast or fibroblasts treated with 5-aza-...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669653/ https://ncbi.nlm.nih.gov/pubmed/33039802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102977 |
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