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USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway
An imbalance in cellular homeostasis occurring as a result of protein misfolding and aggregation contributes to the pathogeneses of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Here, we report the identification of a ubiquitin-specific protease, USP7, as a regulatory sw...
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| Τόπος έκδοσης: | Proc Natl Acad Sci U S A |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7668097/ https://ncbi.nlm.nih.gov/pubmed/33106424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014349117 |
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