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Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins

The principal virulence factor of human pathogenic enterohemorrhagic Escherichia coli is Shiga toxin (Stx). Shiga toxin 2a (Stx2a) is the subtype most commonly associated with severe disease outcomes such as hemorrhagic colitis and hemolytic uremic syndrome. The catalytic A1 subunit (Stx2A1) binds t...

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Foilsithe in:J Biol Chem
Main Authors: Rudolph, Michael J., Davis, Simon A., Tumer, Nilgun E., Li, Xiao-Ping
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667979/
https://ncbi.nlm.nih.gov/pubmed/32878986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC120.015070
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