A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site

Ribonucleotide reductase (RNR) is a central enzyme for the synthesis of DNA building blocks. Most aerobic organisms, including nearly all eukaryotes, have class I RNRs consisting of R1 and R2 subunits. The catalytic R1 subunit contains an overall activity site that can allosterically turn the enzyme...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Martínez-Carranza, Markel, Jonna, Venkateswara Rao, Lundin, Daniel, Sahlin, Margareta, Carlson, Lars-Anders, Jemal, Newal, Högbom, Martin, Sjöberg, Britt-Marie, Stenmark, Pål, Hofer, Anders
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667963/
https://ncbi.nlm.nih.gov/pubmed/32883811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014895
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