Programmable C‐to‐U RNA editing using the human APOBEC3A deaminase

Programmable RNA cytidine deamination has recently been achieved using a bifunctional editor (RESCUE‐S) capable of deaminating both adenine and cysteine. Here, we report the development of “CURE”, the first cytidine‐specific C‐to‐U RNA Editor. CURE comprises the cytidine deaminase enzyme APOBEC3A fu...

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Pubblicato in:EMBO J
Autori principali: Huang, Xinxin, Lv, Junjun, Li, Yongqin, Mao, Shaoshuai, Li, Zhifang, Jing, Zhengyu, Sun, Yidi, Zhang, Xiaoming, Shen, Shengxi, Wang, Xinxin, Di, Minghui, Ge, Jianyang, Huang, Xingxu, Zuo, Erwei, Chi, Tian
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667879/
https://ncbi.nlm.nih.gov/pubmed/33058229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104741
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