Programmable C‐to‐U RNA editing using the human APOBEC3A deaminase

Programmable RNA cytidine deamination has recently been achieved using a bifunctional editor (RESCUE‐S) capable of deaminating both adenine and cysteine. Here, we report the development of “CURE”, the first cytidine‐specific C‐to‐U RNA Editor. CURE comprises the cytidine deaminase enzyme APOBEC3A fu...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Huang, Xinxin, Lv, Junjun, Li, Yongqin, Mao, Shaoshuai, Li, Zhifang, Jing, Zhengyu, Sun, Yidi, Zhang, Xiaoming, Shen, Shengxi, Wang, Xinxin, Di, Minghui, Ge, Jianyang, Huang, Xingxu, Zuo, Erwei, Chi, Tian
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667879/
https://ncbi.nlm.nih.gov/pubmed/33058229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104741
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