Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry

[Image: see text] A bivalent compound 1a featuring both a mu opioid receptor (MOR) and a CXCR4 antagonist pharmacophore (naltrexone and IT1t) was designed and synthesized. Further binding and functional studies demonstrated 1a acting as a MOR and a CXCR4 dual antagonist with reasonable binding affin...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Ma, Hongguang, Wang, Huiqun, Li, Mengchu, Barreto-de-Souza, Victor, Reinecke, Bethany A., Gunta, Rama, Zheng, Yi, Kang, Guifeng, Nassehi, Nima, Zhang, Huijun, An, Jing, Selley, Dana E., Hauser, Kurt F., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667867/
https://ncbi.nlm.nih.gov/pubmed/33214847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00444
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