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Design and Synthesis of a Bivalent Ligand to Explore the Putative Heterodimerization of the Mu Opioid Receptor and the Chemokine Receptor CCR5

The bivalent ligand approach has been utilized not only to study the underlying mechanism of G protein-coupled receptors dimerization and/or oligomerization, but also aimed to enhance ligand affinity and/or selectivity for potential treatment of a variety of diseases by targeting this process. Subst...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Yuan, Yunyun, Arnatt, Christopher K., Li, Guo, Haney, Kendra M., Ding, Derong, Jacob, Joanna C., Selley, Dana E., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374901/
https://ncbi.nlm.nih.gov/pubmed/22354464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob06801j
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