Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35

[Image: see text] FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immunosuppressive properties of thes...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Atack, Thomas C., Raymond, Donald D., Blomquist, Christa A., Pasaje, Charisse Flerida, McCarren, Patrick R., Moroco, Jamie, Befekadu, Henock B., Robinson, Foxy P., Pal, Debjani, Esherick, Lisl Y., Ianari, Alessandra, Niles, Jacquin C., Sellers, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667655/
https://ncbi.nlm.nih.gov/pubmed/33209191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00272
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