Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP

Recently, the US Food and Drug Administration (FDA) approved the first small interfering RNA (siRNA) drug, marking a significant milestone in the therapeutic use of RNA interference (RNAi) technology. However, off-target gene silencing by siRNA remains one of the major obstacles in siRNA therapy. Al...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Zhang, Yao, Teng, Yilan, Xiao, Wangwen, Xu, Beiying, Zhao, Ya, Li, Weihua, Wu, Ligang
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666362/
https://ncbi.nlm.nih.gov/pubmed/33251041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.009
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