In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is required for cell entry and is the primary focus for vaccine development. In this study, we combined cryo–electron tomography, subtomogram averaging, and molecular dynamics simulations to structurally analyze S...

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Udgivet i:Science
Main Authors: Turoňová, Beata, Sikora, Mateusz, Schürmann, Christoph, Hagen, Wim J. H., Welsch, Sonja, Blanc, Florian E. C., von Bülow, Sören, Gecht, Michael, Bagola, Katrin, Hörner, Cindy, van Zandbergen, Ger, Landry, Jonathan, de Azevedo, Nayara Trevisan Doimo, Mosalaganti, Shyamal, Schwarz, Andre, Covino, Roberto, Mühlebach, Michael D., Hummer, Gerhard, Krijnse Locker, Jacomine, Beck, Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665311/
https://ncbi.nlm.nih.gov/pubmed/32817270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd5223
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