Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling

Goblet cell hyperplasia and metaplasia and excessive mucus are prominent pathologies of chronic airway diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and chronic bronchitis. Chronic infection by respiratory pathogens, including Pseudomonas aeruginosa, exacerbate...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Choi, Woosuk, Choe, Shawn, Lin, Jingjun, Borchers, Michael T, Kosmider, Beata, Vassallo, Robert, Limper, Andrew H., Lau, Gee W
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664156/
https://ncbi.nlm.nih.gov/pubmed/32034274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-0262-1
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