Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling

Goblet cell hyperplasia and metaplasia and excessive mucus are prominent pathologies of chronic airway diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and chronic bronchitis. Chronic infection by respiratory pathogens, including Pseudomonas aeruginosa, exacerbate...

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Publicado en:Mucosal Immunol
Autores principales: Choi, Woosuk, Choe, Shawn, Lin, Jingjun, Borchers, Michael T, Kosmider, Beata, Vassallo, Robert, Limper, Andrew H., Lau, Gee W
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664156/
https://ncbi.nlm.nih.gov/pubmed/32034274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-0262-1
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