CRIPTO antagonist ALK4(L75A)-Fc inhibits breast cancer cell plasticity and adaptation to stress

BACKGROUND: CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4(L75A)-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-dependent pl...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Balcioglu, Ozlen, Heinz, Richard E., Freeman, David W., Gates, Brooke L., Hagos, Berhane M., Booker, Evan, Mirzaei Mehrabad, Elnaz, Diesen, Hyrum T., Bhakta, Kishan, Ranganathan, Supraja, Kachi, Masami, Leblanc, Mathias, Gray, Peter C., Spike, Benjamin T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664111/
https://ncbi.nlm.nih.gov/pubmed/33187540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01361-z
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