Neuregulin-1 inhibits CoCl(2)-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice

Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl(2) is not only a hypoxia-mimetic reagent but also an oxidative stress inducer. Here, we found that CoCl(2) induced significant EAAC1 overe...

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Vydáno v:Mol Brain
Hlavní autoři: Kim, Han-Byeol, Yoo, Ji-Young, Yoo, Seung-Yeon, Lee, Jun-Ho, Chang, Wonseok, Kim, Hye-Sun, Baik, Tai-Kyoung, Woo, Ran-Sook
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664014/
https://ncbi.nlm.nih.gov/pubmed/33187547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00686-2
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