Cholesterol-Rich Microdomains Contribute to PAR1 Signaling in Platelets Despite a Weak Localization of the Receptor in These Microdomains

Platelet protease-activated receptor 1 (PAR1) is a cell surface G-protein-coupled receptor (GPCR) that acts as a thrombin receptor promoting platelet aggregation. Targeting the PAR1 pathway by vorapaxar, a PAR1 antagonist, leads to a reduction in ischemic events in cardiovascular patients with a his...

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Udgivet i:Int J Mol Sci
Main Authors: Rabani, Vahideh, Lagoutte-Renosi, Jennifer, Series, Jennifer, Valot, Benoit, Xuereb, Jean-Marie, Davani, Siamak
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7663584/
https://ncbi.nlm.nih.gov/pubmed/33138025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218065
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