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Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC
With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention. Herein, three bestatin-based hydroxamic acids (P1, P2 and P3) were desig...
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| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7662900/ https://ncbi.nlm.nih.gov/pubmed/33126591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25214991 |
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