Hybrid topoisomerase I and HDAC inhibitors as dual action anticancer agents

Recent studies have shown that HDAC inhibitors act synergistically with camptothecin derivatives in combination therapies. To exploit this synergy, new hybrid molecules targeting simultaneously topoisomerase I and HDAC were designed. In particular, a selected multivalent agent containing a camptothe...

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Veröffentlicht in:PLoS One
Hauptverfasser: Cincinelli, Raffaella, Musso, Loana, Artali, Roberto, Guglielmi, Mario B., La Porta, Ilaria, Melito, Carmela, Colelli, Fabiana, Cardile, Francesco, Signorino, Giacomo, Fucci, Alessandra, Frusciante, Martina, Pisano, Claudio, Dallavalle, Sabrina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177136/
https://ncbi.nlm.nih.gov/pubmed/30300374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205018
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