Protein Binding of Lapatinib and Its N- and O-Dealkylated Metabolites Interrogated by Fluorescence, Ultrafast Spectroscopy and Molecular Dynamics Simulations

Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to serum proteins and is readily biotransformed in humans, giving rise to several metab...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Andreu, Inmaculada, Lence, Emilio, González-Bello, Concepción, Mayorga, Cristobalina, Cuquerella, M. Consuelo, Vayá, Ignacio, Miranda, Miguel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662899/
https://ncbi.nlm.nih.gov/pubmed/33192518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.576495
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