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Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs

The four transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) together can convert human fibroblasts to induced pluripotent stem cells (iPSCs). It is, however, perplexing that they can do so only for a rare population of the starting cells with a long latency. Transcription factors (TFs) define id...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cevallos, Ricardo R., Edwards, Yvonne J. K., Parant, John M., Yoder, Bradley K., Hu, Kejin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7661723/
https://ncbi.nlm.nih.gov/pubmed/33184372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76705-y
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