Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2

The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to...

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Vydáno v:PLoS Biol
Hlavní autoři: Nader, Nancy, Dib, Maya, Hodeify, Rawad, Courjaret, Raphael, Elmi, Asha, Hammad, Ayat S., Dey, Raja, Huang, Xin-Yun, Machaca, Khaled
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660923/
https://ncbi.nlm.nih.gov/pubmed/33137110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000901
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