Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2

The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Nader, Nancy, Dib, Maya, Hodeify, Rawad, Courjaret, Raphael, Elmi, Asha, Hammad, Ayat S., Dey, Raja, Huang, Xin-Yun, Machaca, Khaled
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660923/
https://ncbi.nlm.nih.gov/pubmed/33137110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000901
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